Journal
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Volume 38, Issue 10, Pages 666-674Publisher
WILEY
DOI: 10.1111/j.1440-1681.2011.05553.x
Keywords
multi-electrode; remodelling; triggered activity
Categories
Funding
- Centre of Excellence for Clinical Trial and Research in Neuroscience [DOH100-TD-B-111-003]
- Wan Fan Hospital, Taipei Medical University [NSC 97-2314-B-038-030-MY3, NSC 98-2314-B-010-031-MY3, NSC 99-2314-B-075-032, NSC 99-2314-B-016-034-MY3, 100-wf-eva-012]
- CMRPG370141-3
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1. Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2. The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing-induced HF, using a multi-electrode array system and conventional microelectrodes. 3. Compared with the control-PV (n = 21), the HF-PV (n = 13) had a higher incidence and frequency of rapid pacing-induced spontaneous activity (85 vs 29%, P = 0.005; 3.5 +/- 0.2 vs 1.7 +/- 0.1 Hz, P < 0.001) and high-frequency irregular electrical activity (92 vs 38%, P = 0.01; 23 +/- 1 vs 19 +/- 1 Hz, P = 0.003), greater depolarized resting membrane potential (-59 +/- 1 vs -70 +/- 2 mV, P < 0.001), higher incidence of early afterdepolarizations (EAD; 69 vs 6%, P = 0.001) and delayed afterdepolarizations (DAD; 92 vs 25%, P = 0.001), and slower conduction velocity (38 +/- 2 vs 63 +/- 2 cm/s, P < 0.05). In comparison to the HF-LA, the HF-PV had a higher incidence of spontaneous activity and high-frequency irregular electrical activity (85 vs 39%, P = 0.04; 92 vs 46%, P = 0.03), and higher incidence of EAD and DAD, and those differences were not found between the control-LA and control-PV. The control-PV with high-frequency irregular electrical activity had a higher incidence of DAD and spontaneous activity as compared with those without it. 4. HF contributed to an increased automaticity, triggered activity and conduction disturbance in the PV. The PV possessed more arrhythmogenic properties, which might play an important role in the genesis of AF in HF.
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