Journal
JOURNAL OF LARYNGOLOGY AND OTOLOGY
Volume 129, Issue -, Pages S2-S7Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0022215115001322
Keywords
Sinusitis; Cytokines; NF-Kappa B; Transforming Growth Factor Beta
Categories
Ask authors/readers for more resources
Background: Chronic rhinosinusitis is characterised by persistent inflammation of the sinonasal mucosa. Multiple pathophysiological mechanisms are likely to exist. Previous research has focused predominantly on T-helper type cytokines to highlight the inflammatory mechanisms. However, proteins such as nuclear factor kappa B and transforming growth factor beta are increasingly recognised to have important roles in sinonasal inflammation and tissue remodelling. Objective: This review article explores the roles of T-helper type cytokines, nuclear factor kappa B and transforming growth factor beta in the pathophysiological mechanisms of chronic rhinosinusitis. An understanding of these mechanisms will allow for better identification and classification of chronic rhinosinusitis endotypes, and, ultimately, improved therapeutic strategies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available