Journal
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
Volume 4, Issue 1, Pages 52-54Publisher
KOREAN SOC OTORHINOLARYNGOL
DOI: 10.3342/ceo.2011.4.1.52
Keywords
Immunoglobulin G; Hearing loss; Autoimmune disease
Categories
Funding
- SNUBH [02-2008-019]
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IgG4-related systemic disease, including autoimmune pancreatitis, is a multi-organ disorder characterized by elevated serum immunoglobulin G4 (IgG4) concentration and IgG4-positive plasma cell infiltration. We report a case of a 66-years-old woman with IgG4-related hearing disorder, presenting with fluctuating mixed hearing loss with middle ear effusion. The serum IgG4 level was elevated and pathological examination revealed dense infiltration of IgG4-positive lymphocyte in the renal parenchyma, lung tissue and lacrimal gland. With intravenous methylprednisolone at a dose of 60 mg daily, improvement of hearing loss were observed. No recurrence was observed for 6 months with mainternance of prednisolone and methotrexate.
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