Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 27, Pages 7857-7861Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201501995
Keywords
copper; diols; homogeneous catalysis; hypervalent compounds; synthetic methods
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Funding
- EPSRC
- ERC
- EPSRC [EP/I00548X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I00548X/1] Funding Source: researchfish
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A novel method for the synthesis of a wide range of functionalized 1,3-diol derivatives is reported. Employing a copper-catalyzed oxy-alkenylation strategy, a range of readily available, substituted homoallylic alcohol derivatives and alkenyl(aryl) iodonium salts combine to form syn-1,3-carbonates in excellent yield and with high selectivity. Furthermore, the products formed are amenable to an iterative reaction sequence, thus affording highly complex polyketide-like fragments.
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