Journal
CLINICAL AND EXPERIMENTAL NEPHROLOGY
Volume 18, Issue 2, Pages 265-268Publisher
SPRINGER
DOI: 10.1007/s10157-013-0847-z
Keywords
End-stage renal disease; Oxidative stress; Impaired exercise capacity; Skeletal muscle; Adipose tissue; Lipid metabolism; Malnutrition
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Advanced chronic kidney disease (CKD) results in a constellation of dysregulation of lipid metabolism, oxidative stress, and inflammation which are causally interconnected and participate in a vicious cycle. The CKD-associated lipid disorders are marked by impaired clearance of very low density lipoprotein and chylomicrons, hypertriglyceridemia, formation of small dense low-density lipoprotein (LDL), oxidative modification of LDL, intermediate density lipoprotein and chylomicron remnants, and high-density lipoprotein deficiency and dysfunction. This review provides a brief overview of the role of CKD-induced lipid disorders in the pathogenesis of oxidative stress, inflammation, cardiovascular disease, impaired exercise capacity, cachexia and wasting syndrome.
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