Journal
CLINICAL AND EXPERIMENTAL NEPHROLOGY
Volume 17, Issue 5, Pages 631-633Publisher
SPRINGER
DOI: 10.1007/s10157-012-0738-8
Keywords
NETs; PTU; MPO-ANCA; MPO-AAV
Categories
Funding
- Ministry of Health, Labour and Welfare of Japan
- Grants-in-Aid for Scientific Research [24659171] Funding Source: KAKEN
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Neutrophil extracellular traps (NETs) are characterized by the presence of extracellular DNA fibers studded with antimicrobial proteins, including myeloperoxidase (MPO). Although NETs play an important role in the innate immune system, the scattered extracellular enzymes, such as MPO, pose risks to the host. Therefore, NETs are strictly regulated by DNase I in the serum, which prevents them from persisting. Recent studies have demonstrated that dysregulation of NETs could be involved in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus. In this review, we interpret the association of disordered NETs with autoimmune diseases, especially propylthiouracil-induced MPO-ANCA-associated vasculitis.
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