Journal
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Volume 194, Issue 1, Pages 17-26Publisher
WILEY
DOI: 10.1111/cei.13164
Keywords
allergy; T lymphocyte; T helper cell; Th2 polarization; vitamin D receptor
Categories
Funding
- National '13th-5' key programme, Precision medicine research project [2016YFC0905802, 2016YFC0903700]
- Guangdong provincial scientific technological research project [2016A020216029]
- Shenzhen scientific technological basic research project [JCYJ20160429114659119]
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Vitamin D receptor (VDR) mediates various biochemical activities between the cytoplasm and the nucleus in the cell. The nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin domain containing 3 (NLRP3) protein is involved in the T helper type 2 (Th2) response. This study tests a hypothesis that VDR interacts with NLRP3 to restrict the Th2-biased response. In this study, VDR-/- mice and WT (WT) mice were used. Th2 cell differentiation between VDR-/- mice and WT mice was observed. We observed that CD4(+) T cell activation was higher in VDR-/- mice. The VDR(-/-)CD4(+) T cells were prone to Th2 polarization. VDR-/- mice produced more immunoglobulin (Ig)E. VDR bound NLRP3 to prevent Th2 differentiation by restricting IL4 gene transcription. Th2 biased inflammation spontaneously developed in the intestine of VDR-/- mice. In conclusion, VDR binds NLRP3 to restrict IL4 gene transcription and prevent biased Th2 polarization.
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