4.1 Article

Design, synthesis and biological evaluation of deuterated nintedanib for improving pharmacokinetic properties

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Nintedanib: From Discovery to the Clinic

Gerald J. Roth et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Editorial Material Oncology

Study design and clinical evidence in mRCC Can we save axitinib as a first-line therapy?

Roberto Iacovelli et al.

CANCER BIOLOGY & THERAPY (2014)

Editorial Material Oncology

Cabozantinib and Prostate Cancer: Inhibiting Seed and Disrupting Soil?

Richard J. Lee et al.

CLINICAL CANCER RESEARCH (2014)

Article Biochemical Research Methods

Quantitative analyses of CTP-499 and five major metabolites by core-structure analysis

Xiaonan Tang et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2014)

Article Chemistry, Medicinal

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

Thomas G. Gant

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Medicine, General & Internal

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

Luca Richeldi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Biochemistry & Molecular Biology

The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588

Paul W. Manley et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2013)

News Item Biochemistry & Molecular Biology

Heavy drugs draw heavy interest from pharma backers

Alla Katsnelson

NATURE MEDICINE (2013)

Article Chemistry, Medicinal

Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents

Yaoqiu Zhu et al.

ACS MEDICINAL CHEMISTRY LETTERS (2013)

Article Medicine, General & Internal

Ponatinib in Refractory Philadelphia Chromosome-Positive Leukemias

Jorge E. Cortes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Pharmacology & Pharmacy

Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers

Peter Stopfer et al.

XENOBIOTICA (2011)

News Item Multidisciplinary Sciences

Big interest in heavy drugs

Katharine Sanderson

NATURE (2009)

Review Cell Biology

Role of platelet-derived growth factors in physiology and medicine

Johanna Andrae et al.

GENES & DEVELOPMENT (2008)

Review Oncology

Sunitinib: From rational design to clinical efficacy

Laura Q. M. Chow et al.

JOURNAL OF CLINICAL ONCOLOGY (2007)

Review Biotechnology & Applied Microbiology

Discovery and development of sorafenib: a multikinase inhibitor for treating cancer

Scott Wilhelm et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Chemistry, Medicinal

Derivatives of tramadol for increased duration of effect

LM Shao et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)

Review Multidisciplinary Sciences

Angiogenesis as a therapeutic target

N Ferrara et al.

NATURE (2005)

Review Biochemistry & Molecular Biology

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

M Presta et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2005)

Review Oncology

Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis

DJ Hicklin et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

Review Biochemistry & Molecular Biology

Angiogenesis in health and disease

P Carmeliet

NATURE MEDICINE (2003)