Journal
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Volume 168, Issue 1, Pages 30-38Publisher
WILEY
DOI: 10.1111/j.1365-2249.2011.04557.x
Keywords
enterovirus; innate immunity; interferon; RIG-I-like receptors; Type 1 diabetes
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Funding
- Karolinska Institutet, Stockholm, Sweden
- Swedish MRC
- Swedish Diabetes Association Research Foundation
- Swedish Child Diabetes Foundation
- European Union
- European Foundation for the Study of Diabetes
- Oxford University, Oxford, U.K.
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Type 1 diabetes (T1D) is an autoimmune disease arising as a consequence of a misdirected T cell response to the pancreatic beta cell. In recent years, there has been a growing interest in the innate immune system as a regulator of disease development. Genome-wide association studies have identified diabetes-associated polymorphisms in genes encoding proteins with functions related to the innate immune response. Moreover, enteroviruses, known to activate a strong innate immune response, have been implicated in the disease pathogenesis. In this review, we discuss the innate immune response elicited by enteroviruses and how this response may regulate T1D development.
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