Journal
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Volume 165, Issue 3, Pages 292-300Publisher
WILEY
DOI: 10.1111/j.1365-2249.2011.04433.x
Keywords
heat shock proteins; immunoregulation; inflammation
Categories
Funding
- Arthritis Research UK [18152] Funding Source: Medline
- Versus Arthritis [18152] Funding Source: Medline
- Versus Arthritis [18152] Funding Source: researchfish
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The resolution of inflammation is central to the maintenance of good health and immune homeostasis. Recently, several intracellular stress proteins have been described as having extracellular properties that are anti-inflammatory or favour the resolution of inflammation. We propose that these molecules should be defined as resolution-associated molecular patterns (RAMPs). RAMPs are released at times of cellular stress and help to counterbalance the inflammatory effects of pathogen-associated (PAMPs) and damage-associated (DAMPs) molecular patterns. We propose that heat shock protein 10 (HSP10), alpha B-crystallin (alpha BC), HSP27 and binding immunoglobulin protein (BiP) should be considered founding members of the RAMP family. A greater understanding of RAMP biology may herald the development of novel immunotherapies.
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