Journal
CLINICAL AND EXPERIMENTAL HYPERTENSION
Volume 32, Issue 7, Pages 464-468Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/10641963.2010.496516
Keywords
Na+,K+-ATPase; dopamine; angiotensin II; renal proximal tubule; protein kinase C; adenylyl cyclase
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Accumulated studies reported that the natruretic dopamine (DA) and the anti-natruretic angiotensin II (Ang II) represent an important mechanism to regulate renal Na+ and water excretion through intracellular secondary messengers to inhibit or activate renal proximal tubule (PT) Na+,K+-ATPase (NKA). The antagonistic actions were mediated by the phosphorylation of different position of NKA alpha(1)-subunit and different Pals-associated tight junction protein (PATJ) PDZ domains, the different protein kinase C (PKC) isoforms (PKC-beta, PKC-zeta), the common adenylyl cyclase (AC) pathway, and the crosstalk and balance between DA and Ang II to NKA regulation. Besides, Ang II-mediated NKA modulation has bi-phasic effects.
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