Journal
CLINICAL AND EXPERIMENTAL HYPERTENSION
Volume 31, Issue 7, Pages 534-543Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/10641960902825461
Keywords
association study; gene-gene interaction; haplotype; heme oxygenase; hypertension; tagSNPs
Funding
- National Basic Research Program of China [2006CB503805]
- 863 Program of China [2006AA02Z170]
- Beijing Natural Science Foundation [7061006]
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Heme oxygenase was regarded as a regulator of oxidative stress, which was believed to underlie the etiology of hypertension. To assess the effect of its encoded genes (HMOX1 and HMOX2) on hypertension, we designed a case-control study in 503 cases and 490 controls. The results indicated that the rs9607267 of the HMOX1 gene was significantly associated with essential hypertension (EH) and the Hap3(T-C-G) of the HMOX1 gene was also significantly associated with the risk of EH. No association was observed between the HMOX2 gene and EH. The multifactor-dimensionality reduction analyses results did not show any interaction between the HMOX1 and HMOX2 genes underlying the development of hypertension.
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