Journal
CLINICAL AND EXPERIMENTAL DERMATOLOGY
Volume 38, Issue 1, Pages 44-46Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2230.2012.04375.x
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Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63-year-old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and haematological diseases.
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