Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 48, Pages 14527-14530Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201507831
Keywords
hyperpolarization; multidimensional NMR spectroscopy; para-hydrogen; signal amplification; trace analysis
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Funding
- European Union
- province of Gelderland
- province of Overijssel
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Nuclear magnetic resonance is often the technique of choice in chemical analysis because of its sensitivity to molecular structure, quantitative character, and straightforward sample preparation. However, determination of trace analytes in complex mixtures is generally limited by low sensitivity and extensive signal overlap. Here, we present an approach for continuous hyperpolarization at high magnetic field that is based on signal amplification by reversible exchange (SABRE) and can be straightforwardly incorporated in multidimensional NMR experiments. This method was implemented in a 2D correlation experiment that allows detection and quantification of analytes at nanomolar concentration in complex solutions.
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