Journal
CLINICAL AND EXPERIMENTAL ALLERGY
Volume 38, Issue 12, Pages 1911-1920Publisher
WILEY
DOI: 10.1111/j.1365-2222.2008.03087.x
Keywords
allergy; asthma; children; endotoxin; house dust
Categories
Funding
- European Commission [QLK4-CT-1999-01288]
- European members of the ISAAC Steering Committee
- South Thames National Health Service Regional Research and Development project [SPGS 573]
- Swedish Foundation for Health Care Sciences and Allergy Research
- Health Research Council of New Zealand
- Asthma and Respiratory Foundation of New Zealand
- Hawkes Bay Medical Research Foundation
- German Academic Exchange Service (DAAD)
- Netherlands Organization for Scientific Research (NWO)
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Several studies have consistently reported inverse associations between exposure to endotoxin in house dust and atopy. With regard to the association between house dust endotoxin and asthma, the results are inconsistent. To study the association between house dust endotoxin levels and respiratory symptoms and atopy in populations from largely different countries. Data were collected within the International Study on Asthma and Allergies in Childhood Phase Two, a multi-centre cross-sectional study of 840 children aged 9-12 years from six centres in the five countries of Albania, Italy, New Zealand, Sweden and the United Kingdom. Living room floor dust was collected and analysed for endotoxin. Health end-points and demographics were assessed by standardized questionnaires. Atopy was assessed by measurements of allergen-specific IgE against a panel of inhalant allergens. Associations between house dust endotoxin and health outcomes were analysed by logistic regression. Odds ratios (ORs) were presented for an overall interquartile range increase in exposure. Many associations between house dust endotoxin in living room floor dust and health outcomes varied between countries. Combined across countries, endotoxin levels were inversely associated with asthma ever [adjusted OR (95% confidence interval (CI)) 0.53 (0.29-0.96) for endotoxin levels per m(2) of living room floor] and current wheeze [adjusted OR (95% CI) 0.77 (0.64-0.93) for endotoxin levels per gram of living room floor dust]. There were inverse associations between endotoxin concentrations and atopy, which were statistically significant in unadjusted analyses, but not after adjustment for gender, parental allergies, cat and house dust mite allergens. No associations were found with dust quantity and between endotoxin exposure and hayfever. These findings suggest an inverse association between endotoxin levels in living room floor dust and asthma in children. Cite this as: U. Gehring, M. Strikwold, D. Schram-Bijkerk, G. Weinmayr, J. Genuneit, G. Nagel, K. Wickens, R. Siebers, J. Crane, G. Doekes, R. Di Domenicantonio, L. Nilsson, A. Priftanji, A. Sandin, N. El-Sharif, D. Strachan, M. van Hage, E. von Mutius, B. Brunekreef and the ISAAC Phase Two Study Group, Clinical and Experimental Allergy, 2008 (38) 1911-1920.
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