Journal
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
Volume 16, Issue 1, Pages 99-102Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1076029608323498
Keywords
endoplasmic reticulum stress; XBP1; obesity
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Funding
- Ankara University
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Endoplasmic reticulum stress is a central feature of obesity, insulin resistance, and type 2 diabetes. A polymorphism of the XBP1 gene (-116C/G), a transcription factor that modulates the endoplasmic reticulum stress response, Causes an impairment of its positive feedback system. The authors examined a role of the polymorphism in the development of obesity. The polymorphism was investigated in clinically obese children and compared with controls. Significant difference of genotype distribution was observed, which suggested that the -116C/G genotype may be a risk factor for at least pediatric obesity.
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