Journal
CLINICAL & TRANSLATIONAL ONCOLOGY
Volume 15, Issue 10, Pages 796-801Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s12094-013-1009-1
Keywords
c-Myb; Cyclin D1; Esophageal squamous cell carcinoma; Proliferation
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Funding
- National Natural Science Foundation of China [30972937]
- Specialized Research Fund for the Doctoral Program of Higher Education [20070246131]
- Jiangsu six personnel peak talent [2006113]
- Natural Science Foundation of Jiangsu province [BK2006546, BK2009156, BK2009157, BK2009161]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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The c-Myb transcription factor controls differentiation and proliferation in hematopoietic and other cell types, and has latent in regulation during the cell cycle. Recent studies suggested that deregulation of c-Myb expression plays a key role in oncogenesis. To investigate the potential roles of c-Myb in esophageal carcinoma, expression of c-Myb was examined in human esophageal carcinoma samples. Immunohistochemistry and Western blot analysis were performed for c-Myb in 87 esophageal carcinoma samples. The data were correlated with clinicopathological features. The univariate and multivariate survival analyses were also performed to determine their prognostic significance. c-Myb was overexpressed in esophageal carcinoma as compared with the adjacent normal tissue. High expression of c-Myb was associated with histological grade and was positively correlated with proliferation marker Ki-67 (P = 0.001). Univariate analysis showed that c-Myb expression was associated with poor prognosis (P < 0.001). Multivariate analysis indicated that c-Myb was an independent prognostic marker for esophageal carcinoma (P < 0.001). While in vitro, following release from serum starvation of TE-1 esophageal carcinoma cell, the expression of c-Myb was upregulated. Our results suggested that c-Myb overexpression is involved in the pathogenesis of esophageal carcinoma; it may be a favorable independent poor prognostic parameter for esophageal carcinoma.
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