Journal
CLINICAL & EXPERIMENTAL METASTASIS
Volume 27, Issue 6, Pages 409-418Publisher
SPRINGER
DOI: 10.1007/s10585-009-9297-0
Keywords
Metastasis; RSV; v-Src; Syngenic; Oligo array; Cytokines
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Funding
- European Union
- Institut du Cancer
- Canceropole Ile de France
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We compared gene expression patterns related to cancer progression, cell adhesion and cytokine expression in v-Src-transformed isogenic cell lines with different levels of metastatic aggressiveness in syngenic animals: a high (HM) and a low metastatic (LM) cell lines, both predetermined by in vitro oncogenic transformation, and a high metastatic (NM) cell line resulting from in vivo selection of grafted LM cells. While LM and NM shared a common v-Src transforming variant different from that of HM, gene expression patterns were similar in HM and NM but different from that of LM. In this model, the induction of the metastatic phenotype by an oncogene variant or by the host environment led to highly similar expression profiles. If confirmed in other models, these results would be relevant for the diagnosis and treatment of metastasis.
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