Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 34, Pages 9931-9935Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201503528
Keywords
bis-aryl stereocenters; enantioselective catalysis; heterocycles; organocatalysis; trifluoroborate salts
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Funding
- Welch Foundation [E-1744]
- CBIP (UH)
- Studying Abroad Scholarship of Taiwan
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Bis-heteroaryl or bis-aryl stereocenters were formed by an organocatalytic enantioselective conjugate addition using the respective trifluoroborate salts as nucleophiles. Control studies suggested that fluoride dissociation is necessary in the anhydrous conditions. This strategy is applicable to the synthesis of discoipyrrole D, an inhibitor of BR5 fibroblast migration.
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