Journal
CLINICAL & DEVELOPMENTAL IMMUNOLOGY
Volume -, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2012/762541
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Funding
- Estonian Science Foundation [ETF4631, ETF6514, ETF5796, ETF6498]
- Estonian Ministry of Education and Research [SF0182586s03, SF0180044s09]
- Enterprise Estonia [EU30200]
- Estonia-France Parrot grant
- Centre of Molecular and Clinical Medicine, University of Tartu
- scholarship of Andreas and Dr. Elmerice Traks
- UHP-BQRI in Faculte de Medecine et CHU de Nancy, Universite Henri Poincare, Nancy, France
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Female fertility can be affected by diseases or dysfunctions of reproductive tract, neuroendocrine system, and immune system. Reproductive autoimmune failure can be associated with overall activation of immune system or with immune system reactions specifically directed against ovarian antigens. Majority of the antiovarian autoantibodies are directed against beta-subunit of follicle stimulating hormone (anti-FSH). This paper summarizes a current clinical classification of female infertility in the context of general activation of autoimmunity and antiovarian autoimmunity by describing serum anti-FSH. The presence of naturally occurring anti-FSH in healthy women will be discussed. In addition, the putative impairment of ovarian folliculogenesis in case of increased production of those antibodies in infertile women will be characterized.
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