Journal
CLINICA CHIMICA ACTA
Volume 431, Issue -, Pages 33-39Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2014.01.012
Keywords
IL-17A; IL-17RA; IL-17RC; Lipid metabolism; Atherosclerosis
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Funding
- National Natural Sciences Foundation of China [81170278, 81370377, 81300224]
- Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2008-244]
- construct program of the key discipline in Hunan Province, China
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Interleukin-17 (IL-17) A, the most important cytokine of the IL-17 family predominantly secreted by T helper 17 (Th17) cells, plays a critical role in the development of inflammatory diseases. Its receptor is an obligate heterodimer composed of IL-17 receptor (IL-17R) A and C, the main members of the IL-17R family. Binding of IL-17A to the IL-17RA/C complex can activate a variety of downstream signaling pathways such as nuclear factor kappa-B (NF-kappa B), activator protein 1 (AP1) and CCAAT/enhancer-binding protein (C/EBP) to induce the expression of proinflammatory cytokines and chemokines. IL-17A also promotes mRNA stability. Growing evidence shows that IL-17A is involved in lipid metabolism and the pathogenesis of atherosclerosis, a chronic inflammatory arterial disease driven by both innate and adaptive immune responses to modified lipoproteins. In the current review, we describe recent progress on regulation and signaling of IL-17A, and highlight its impacts on lipid metabolism and atherosclerosis. (C) 2014 Elsevier B.V. All rights reserved.
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