Journal
CLINICA CHIMICA ACTA
Volume 431, Issue -, Pages 185-191Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2014.01.019
Keywords
Galectin-3 (Gal-3); Cancer; Expression; Mechanism; Location
Categories
Funding
- Financial Department of Liaoning Province [(2012)1203]
- Educational Department of Liaoning Province [L2012329, 2013356]
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Galectin-3 (Gal-3) plays important roles in cell proliferation, adhesion, differentiation, angiogenesis and apoptosis in normal and pathologic tissues. Accumulated evidences indicate that Gal-3 is closely involved in tumor cell transformation, migration, invasion and metastasis. In this review, the associations of the expression and localization of Gal-3 as well as its potential action mechanism in tumorigenesis in a variety of cancers were summarized and concluded. Gal-3 is gaining its attraction as a potential new biomarker for the diagnosis, treatment and prognosis of certain tumors. (C) 2014 Elsevier B.V. All rights reserved.
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