Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 135, Issue 7, Pages 1713-1714Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jid.2015.92
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Debate over the pathogenesis of vitiligo is still ongoing among scientists, with several hypotheses currently under consideration. The study by Wagner et al. in this issue focuses on the role of E-cadherin-mediated cell adhesion in vitiliginous epidermis under oxidative and mechanical stress. Their work highlights how alterations in cell-cell adhesion across nonlesional melanocyte membranes in patients with vitiligo argue for primary intrinsic defects in the melanocytes.
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