Journal
CLINICA CHIMICA ACTA
Volume 412, Issue 19-20, Pages 1702-1711Publisher
ELSEVIER
DOI: 10.1016/j.cca.2011.06.007
Keywords
Anorexia nervosa; Adipocytokines; Gut hormones; Insulin sensitivity; Regulation of appetite
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Anorexia nervosa is a complex eating disorder of unknown etiology which affects adolescent girls and young women and leads to chronic malnutrition. Clinical manifestations of prolonged semistarvation include a variety of physical features and psychiatric disorders. The study of different biological factors involved in the pathophysiology of anorexia nervosa is an area of active interest. In this review we have described the role of adipocytokines, neurotrophins, peptides of the gastrointestinal system and growth factors in appetite regulation, energy balance and insulin sensitivity in anorexia nervosa patients. (C) 2011 Elsevier B.V. All rights reserved.
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