Journal
CLINICA CHIMICA ACTA
Volume 411, Issue 17-18, Pages 1172-1180Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2010.04.032
Keywords
Group A streptococci; M protein
Categories
Funding
- foundation of Alfred Osterlund
- foundation of Crafoord
- foundation of Greta and Johan Kock
- Blood and Defence Network
- Vascular Wall Programme at Lund University
- Medical Faculty, Lund University
- Swedish Research Council [21112, 6563, 7480, 5615]
- Hansa Medical AB
- European Commission [219261]
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Group A streptococci (GAS, Streptococcus pyogenes) are exclusive human pathogens that have been extensively studied for many decades. The spectrum of diseases caused by these bacteria ranges from uncomplicated and superficial to severe and invasive infections. In order to give rise to these complications, GAS have evolved a number of surface-bound and secreted virulence factors, of which the M proteins are probably the best characterized. Evidence has emerged that M proteins are multifunctional pathogenic determinants, and over the years many interactions between M proteins and the human host have been reported. The present review article aims to present a state-of-the-art overview of the most important virulence mechanisms employed by M proteins to trigger disease. (C) 2010 Elsevier B.V. All rights reserved.
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