Journal
CLINICA CHIMICA ACTA
Volume 400, Issue 1-2, Pages 21-24Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2008.09.028
Keywords
RTN4; Dilated cardiomyopathy; Polymerase chain reaction; Polymorphism; Allele
Categories
Funding
- National Natural Science Foundation of China [30871044]
- Key Project of Chinese Ministry of Education [106135]
- Doctoral Fund of Ministry of Education of China [20070610144]
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Background: The Nogo isoforms A, B and C are members of the reticulon family of proteins. Nogo-B is found in most tissues, especially highly expressed in endothelial and smooth muscle cells of the vessel wall, and Nogo-B is a regulator of cell migration in vitro and vascular remodeling in vivo. The TATC and CAA 3'UTR insertion/deletion polymorphisms of the RTN4. the gene encoding Nogo isoforms A, B and C, have been linked to schizophrenia and depression, but data were inconsistent. However, it is unclear whether these polymorphisms are associated with dilated cardiomyopathy (DCM). Methods: A total of 159 DCM patients and 215 control subjects were recruited in this study. The RTN4 TATC and CAA insertion/deletion genotypes were determined using PCR-polyacrylamide gel electrophoresis. Results: Frequencies of (TATC)(2) allele and (TATC)(2)/(TATC)(2) genotype were significantly different from that in healthy controls (P = 0.045. OR = 1.356. 95% CI = 1.006-1.827 and P = 0.021, OR = 2.094. 95% CI = 1.113-3.940, respectively). No significant differences in CAA insertion/deletion genotype and allele frequencies were observed between the DCM and controls. Conclusion: These data provide evidence that RTN4 allele (TATC)(2) and (TATC)(2)/(TATC)(2) genotype are associated with DCM. (C) 2008 Elsevier B.V. All rights reserved.
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