4.8 Article

α-Arylation/Heteroarylation of Chiral α-Aminomethyltrifluoroborates by Synergistic Iridium Photoredox/Nickel Cross-Coupling Catalysis

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 1, Pages 254-258

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201506147

Keywords

amino acids; cross-coupling; heterocycles; nickel; photochemistry

Funding

  1. National Institute of General Medical Sciences [R01-GM113878]
  2. CAPES (Coordenacao de Aperfeicoamento Pessoal de Nivel Superior) [012849/2013-08]

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Direct access to complex, enantiopure benzylamine architectures using a synergistic iridium photoredox/nickel cross-coupling dual catalysis strategy has been developed. New C(sp(3)) C(sp(2)) bonds are forged starting from abundant and inexpensive natural amino acids.

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