Journal
CLEFT PALATE-CRANIOFACIAL JOURNAL
Volume 51, Issue 2, Pages 246-251Publisher
ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS
DOI: 10.1597/12-245
Keywords
ankyloglossia; hemifacial microsomia; keratinocytes; scaffold; tissue engineering
Categories
Funding
- Spanish ISCIII [PI11/0125]
- Comunidad de Madrid [P2010BMD-2359, P2010BMD-2420]
- MICINN [SAF2010-16976]
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Many types of soft tissue grafts have been used for the reconstruction of oral mucosal defects. The best results are achieved with mucosal grafts; however, when large areas must be grafted, sufficient donor tissue is not available. Tissue engineering represents an alternative method to obtain sufficient autologous tissue for reconstructing oral wounds. Herein we present a pediatric patient with hemifacial microsomia and congenital ankyloglossia requiring multiple surgical interventions, and in which an autologous full-thickness tissue-engineered oral mucosa was used for successful oral reconstruction. Our study demonstrates that even under challenging conditions, robust tissue-engineered products, such as the fibrin-based oral mucosa described here, can achieve successful tissue regeneration.
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