Journal
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Volume 35, Issue 2, Pages 100-107Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jir.2014.0054
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Funding
- UWA Research Development Award
- Scholarship for International Research Fees (SIRF)
- University Postgraduate Award for International Students (UPAIS)
- University of Western Australia, WA, Australia
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Combination immunotherapy has resulted in a number of impressive outcomes in mouse models and clinical settings. In this study, we report that a timed triple immunotherapy (TTI) protocol using 3 agonist antibodies (anti-CD25mAb, anti-TGF-beta mAb, and anti-CTLA-4mAb) produced complete clearance of established AB1 murine mesothelioma tumors. Combining all 3 agonist antibodies into a single cocktail for intratumoral injection was as effective as the TTI in tumor eradication. Cured mice showed elevated levels of tumor-specific IgG antibodies at 95 days posttreatment. Time-course studies of tumor clearance showed (1) that IgG levels were not elevated during tumor clearance and (2) that B-cell numbers were increased in the tumor-draining lymph nodes and spleens during tumor clearance. Finally, employment of B-cell knockout mice indicated a significant role for B cells in the successful eradication of the established tumors by the triple immunotherapy cocktail.
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