Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 42, Pages 12492-12496Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201412302
Keywords
enantioselective catalysis; hydroacylation; N-heterocyclic carbenes; organocatalysis
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Funding
- Fonds der Chemischen Industrie
- Deutsche Forschungsgemeinschaft [SPP 1179, IRTG 2027]
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A highly enantioselective intramolecular N-heterocyclic carbene (NHC)-catalyzed hydroacylation reaction gives access to a range of cyclic ketones from unactivated olefin-substituted aldehydes (up to 99% ee). Remarkably, aliphatic aldehydes were also transformed efficiently in an NHC-catalyzed hydroacylation reaction for the first time.
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