Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 33, Pages 9691-9695Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201504027
Keywords
colloidosomes; sensors; silver nanoparticles; surface-enhanced Raman scattering; toxin
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Funding
- Singapore National Research Foundation [NRF-NRFF2012-04]
- A*STAR, Singapore
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Colloidosomes are robust microcapsules attractive for molecular sensing because of their characteristic micron size, large specific surface area, and dual-phase stability. However, current colloidosome sensors are limited to qualitative fluorogenic receptor-based detection, which restrict their applicability to a narrow range of molecules. Here, we introduce plasmonic colloidosome constructed from Ag nanocubes as an emulsion-based 3D SERS platform. The colloidosomes exhibit excellent mechanical robustness, flexible size tunability, versatility to merge, and ultrasensitivity in SERS quantitation of food/industrial toxins down to sub-femtomole levels. Using just 0.5L of sample volumes, our plasmonic colloidosomes exhibit >3000-fold higher SERS sensitivity over conventional suspension platform. Notably, we demonstrate the first high-throughput multiplex molecular sensing across multiple liquid phases.
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