Journal
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
Volume 1, Issue 1, Pages 54-61Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCEP.108.764621
Keywords
atrioventricular block; cell therapy of bradyarrhythmias; gene therapy; gene therapy of bradyarrhythmias; hyperpolarization-activated, cyclic nucleotide-gated channels
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Funding
- NHLBI NIH HHS [HL-28958] Funding Source: Medline
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The prevention and treatment of life-threatening bradyarrhythmias have been revolutionized in the last half century by electronic pacemakers. Because this represents a palliative therapy, attempts have begun to effect a cure with the novel tools of gene and cell therapy. Over time. the strategies used have coalesced to focus on achieving a stable and autonomically responsive cardiac rhythm in a setting that ultimately would require no implanted hardware. In this report, we review the history of the disease process being treated, approaches now in progress, and the demands that must be met if biological therapies are to be successful. (Circ Arrhythmia Electrophysiol. 2008;1:54-61.)
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