Journal
CIRCULATION RESEARCH
Volume 123, Issue 7, Pages 773-786Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.118.312497
Keywords
aging; disease; epigenomics; genomics; histones
Funding
- Chinese Academy of Sciences [XDA16010100]
- National Key Research and Development Program of China [2015CB964800, 2017YFA0103304, 2017YFA0102802, 2014CB910503, 2018YFA0107203]
- National Natural Science Foundation of China [81625009, 81330008, 91749202, 91749123, 81371342, 81471414, 81422017, 31671429, 81601233, 81671377, 31601109, 31601158, 81771515, 81822018, 81870228, 81801399, 81801370, 31801010, 81701388]
- National High Technology Research and Development Program of China [2015AA020307]
- CAS [KJZDEW-TZ-L05, CXJJ-16M271]
- Program of Beijing Municipal Science and Technology Commission [Z151100003915072]
- Thousand Young Talents Program of China
- Advanced Innovation Center for Human Brain Protection [117212]
- Beijing Municipal Commission of Health and Family Planning [PXM2018_026283_000002]
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Aging is associated with a progressive decline in cardiovascular structure and function. Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a complex interplay of DNA methylation, histone posttranslational modifications, and dynamic nucleosome occupancy governed by numerous epigenetic factors. Advances in genomics technology have led to a profound understanding of chromatin reorganization in both cardiovascular aging and diseases. This review summarizes recent discoveries in epigenetic mechanisms involved in cardiovascular aging and diseases and discusses potential therapeutic strategies to retard cardiovascular aging and conquer related diseases through the rejuvenation of epigenetic signatures to a young state.
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