Journal
CIRCULATION RESEARCH
Volume 123, Issue 4, Pages 406-408Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.118.313400
Keywords
Alzheimer disease; blood-brain barrier; dementia; neurons; risk factors
Funding
- National Institutes of Health [R37-NS089323, R01-NS100447, R01-NS09544, R01-NS/HL037853, K24-AG052573, RF1-AG050745, R01-AG040282]
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Alzheimer disease (AD)-the leading cause of cognitive impairment in the elderly-has traditionally been considered a disease of neurons. Structural and functional alterations of cerebral blood vessels also occur, but direct evidence of a causal involvement in the pathobiology of the disease has been lacking. This viewpoint will review new data that may help shed light into the intriguing association between vascular and neurodegenerative pathology.
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