Journal
CIRCULATION RESEARCH
Volume 115, Issue 6, Pages 546-548Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.114.304855
Keywords
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Funding
- NHLBI NIH HHS [HL-085577, P01 HL085577, HL-075573, R01 HL104535, HL104535, R01 HL075573] Funding Source: Medline
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The endoplasmic reticulum (ER) stress-inducible transcription factor, x-box binding protein 1 (XBP1), which enhances protein glycosylation in the ER, was shown to also enhance protein glycosylation outside the ER, via a process called O-GlcNAcylation, which protected the heart from ischemia/reperfusion damage.
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