Journal
CIRCULATION RESEARCH
Volume 114, Issue 8, Pages 1311-1319Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.114.300568
Keywords
atrial fibrillation; heart failure; phosphorylation; ryanodine receptor type 2
Funding
- Fondation Leducq grants European-North American Atrial Fibrillation Research Alliance [07CVD03]
- Alliance for Calmodulin Kinase Signaling in Heart Disease [08CVD01]
- European Network for Translational Research in Atrial Fibrillation [261057]
- DZHK (German Center for Cardiovascular Research)
- American Heart Association [13EIA14560061]
- Muscular Dystrophy Association [186530]
- National Institutes of Health grants [HL089598, HL091947, HL117641]
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Cardiac ryanodine receptor type 2 plays a key role in excitation-contraction coupling. The ryanodine receptor type 2 channel protein is modulated by various post-translational modifications, including phosphorylation by protein kinase A and Ca2+/calmodulin protein kinase II. Despite extensive research in this area, the functional effects of ryanodine receptor type 2 phosphorylation remain disputed. In particular, the potential involvement of increased ryanodine receptor type 2 phosphorylation in the pathogenesis of heart failure and arrhythmias remains a controversial area, which is discussed in this review article.
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