Journal
CIRCULATION RESEARCH
Volume 114, Issue 3, Pages 538-548Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.114.301236
Keywords
cardiomyopathies; cell nucleus; myocytes; cardiac
Funding
- National Heart, Lung, and Blood Institute
- AHA [13POST17060120, 12POST12030256]
- California Institute for Regenerative Medicine (CIRM) [TG2-01154]
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The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of proteins within the inner and the outer nuclear membranes, connects the nuclear lamina to the cytoskeleton. The importance of this complex has been highlighted by the discovery of mutations in genes encoding LINC complex proteins, which cause skeletal or cardiac myopathies. Herein, this review summarizes structure, function, and interactions of major components of the LINC complex, highlights how mutations in these proteins may lead to cardiac disease, and outlines future challenges in the field.
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