Journal
CIRCULATION RESEARCH
Volume 112, Issue 11, Pages 1506-1519Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.113.300512
Keywords
immune responses; inflammation; platelets; vasculopathy; vessel diseases
Funding
- National Institutes of Health
- National Center for Research Resources [R37HL044525, R01HL092746, R01HL066277, R01HL100121, R01HL091754, K23HL092161, HL12311, ULI-RR025764]
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Platelets are chief effector cells in hemostasis. In addition, they are multifaceted inflammatory cells with functions that span the continuum from innate immune responses to adaptive immunity. Activated platelets have key thromboinflammatory activities in a variety of vascular disorders and vasculopathies. Recently identified inflammatory and immune activities provide insights into the biology of these versatile blood cells that are directly relevant to human vascular diseases.
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