Journal
CIRCULATION RESEARCH
Volume 112, Issue 3, Pages 534-548Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.111.250266
Keywords
chemical biology; functional genomics; high throughput screening; induced pluripotent stem cells
Funding
- California Institute for Regenerative Medicine [RC1-00132]
- Mathers Charitable Foundation
- Fondation Leducq Transatlantic Alliance
- National Institutes of Health [R01 HL113601]
- California Institute for Regenerative Medicine
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The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells exhibiting inherited traits and disorders. Use of these cells in high throughput analyses should broaden our insight into fundamental disease mechanisms and provide many benefits for patients, including new therapeutics and individually tailored therapies. Here we review recent progress in generating induced pluripotent stem cell-based models of cardiovascular disease and their multiple applications in drug development. (Circ Res. 2013;112:534-548.)
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