Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 13, Pages 3912-3916Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201410548
Keywords
aggregation; chromophores; DNA detection; excimers; fluorescence
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Funding
- National Research Foundation (NRF) - Korean government [2013M2B2A4041354, 2012R1A1A2038694, 2013R1A1A2011320]
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A family of organic chromophores that, like pyrene, forms emissive excimers is reported. Their chemical and photophysical properties are superior to pyrene for the design of chemo- and biosensors. Unlike hydrophobic pyrene, which requires excitation by cell-damaging UV irradiation, these polar dyes absorb strongly in the visible range, and their excimers emit brightly in the red to far-red region of the electromagnetic spectrum. The intensity of the emission signal is greatly increased upon formation of a preassociated dimer that is triggered upon aggregation or crystallization. In demonstration of the potential of this new family of excimer-forming dyes, a probe that is capable of detecting label-free DNA in water down to 10 pm and also doubles as a visualization agent for DNA in gel electrophoresis is reported.
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