Journal
CIRCULATION RESEARCH
Volume 110, Issue 9, Pages 1252-1263Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.111.246116
Keywords
aging; angiogenesis
Funding
- National Institutes of Health
- Leducq Foundation Network of Research Excellence
- Leducq Foundation
- Finnish Cultural Foundations' Post Doc Pool
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Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of both cardiovascular diseases and their adverse sequelae in the elderly. Angiogenesis is both an essential adaptive response to physiological stress and an endogenous repair mechanism after ischemic injury. In addition, induction of angiogenesis is a promising therapeutic approach for ischemic diseases. For these reasons, understanding the basis of age-related impairment of angiogenesis and endothelial function has important implications for understanding and managing cardiovascular disease. In this review, we discuss the molecular mechanisms that contribute to impaired angiogenesis in the elderly and potential therapeutic approaches to improving vascular function and angiogenesis in aging patients. (Circ Res. 2012;110:1252-1263.)
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