Journal
CIRCULATION RESEARCH
Volume 108, Issue 1, Pages 129-152Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.110.223792
Keywords
cardiac development; cardiac differentiation; myocyte regeneration; regeneration; stem cells
Funding
- British Heart Foundation (BHF) Centre for Research Excellence at Imperial College London
- BHF Simon Marks Chair in Regenerative Cardiology
- BHF [RG/08/007]
- European Research Council
- Medical Research Council-BHF Cardiovascular Stem Cell Research
- Medical Research Council
- BHF Centre for Research Excellence at Oxford University
- MRC [G0901467] Funding Source: UKRI
- British Heart Foundation [RG/08/007/25296, PG/09/082/28020] Funding Source: researchfish
- Medical Research Council [G0901467, G1000801a] Funding Source: researchfish
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Cardiac muscle creation during embryogenesis requires extracellular instructive signals that are regulated precisely in time and space, intersecting with intracellular genetic programs that confer or fashion the ability of the cells to respond. Unmasking the essential signals for cardiac lineage decisions has paramount importance for cardiac development and regenerative medicine, including the directed differentiation of progenitor and stem cells to a cardiac muscle fate. (Circ Res. 2011;108:129-152.)
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