Journal
CIRCULATION RESEARCH
Volume 106, Issue 1, Pages 47-57Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.109.207456
Keywords
cardiac failure; fibroblasts; cardiac differentiation; cytokines; growth factors
Funding
- National Institutes of Health [HL092930, AG032977]
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Cardiac fibroblasts are emerging as key components of normal cardiac function, as well as the response to stressors and injury. These most numerous cells of the heart interact with myocytes via paracrine mechanisms, alterations in extracellular matrix homeostasis, and direct cell-cell interactions. It is possible that they are a contributor to the inability of adult myocytes to proliferate and may influence cardiac progenitor biology. Furthering our understanding of how cardiac fibroblasts and myocytes interact may provide an avenue to novel treatments for heart failure prevention. This review discusses the most recent concepts in cardiac fibroblast-myocyte communication and areas of potential future research. (Circ Res. 2010;106:47-57.)
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