Journal
CIRCULATION RESEARCH
Volume 104, Issue 4, Pages 442-454Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.108.191270
Keywords
endothelial cells; Dicer; gene expression; VEGF; cancer
Funding
- NIH [R01 HL64793, R01 HL 61371, R01 HL 57665, P01 HL 70295]
- National Heart, Lung, and Blood-Yale Proteomics [N01-HV-28186]
- Scientist Development Grant from the American Heart Association
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MicroRNAs are short noncoding RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many aspects of development, homeostasis, and disease. Endothelial cells are key regulators of different aspects of vascular biology, including the formation of new blood vessels (angiogenesis). Here, we review the approaches and current experimental evidence for the involvement of miRNAs in the regulation of the angiogenic process and their potential therapeutic applications for vascular diseases associated with abnormal angiogenesis. (Circ Res. 2009;104:442-454.)
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