Journal
CIRCULATION JOURNAL
Volume 78, Issue 11, Pages 2569-2576Publisher
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.CJ-14-1080
Keywords
Autophagy; Diabetes mellitus; Insulin; Left ventricular dysfunction
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Funding
- National Institutes of Health [RO1 HL108379]
- German Research Foundation (DFG)
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Autophagy is a conserved cellular process that plays an important role in cardiovascular homeostasis. Basal levels of autophagy are required for the maintenance of organellar quality control. Autophagy is dynamically regulated in the heart in the fasting to re-feeding transition. Insulin signaling plays an important role in the regulation of myocardial fuel metabolism, mitochondrial function and cellular growth. Recent studies have suggested an important role for insulin signaling in the regulation of myocardial autophagy. This dynamic regulation of autophagy induction during fasting may contribute to organellar homeostasis and if perturbed under conditions of hyperinsulinemia could contribute to accelerated cardiac aging.
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