Journal
CIRCULATION JOURNAL
Volume 78, Issue 6, Pages 1272-1282Publisher
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.CJ-14-0419
Keywords
Arrhythmia; Atrial fibrillation; Remodeling; Sick sinus syndrome; Sinoatrial node
Categories
Funding
- British Heart Foundation [FS/13/31/30189] Funding Source: researchfish
- British Heart Foundation [FS/13/31/30189] Funding Source: Medline
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The sinoatrial node (SAN) is the normal pacemaker of the heart. During a human lifetime it must initiate approximately 2 billion heartbeats and coordinate the cardiovascular response to our physiological and emotional demands. Disease of the SAN is common, and one of the leading indications for electronic pacemaker implantation. Advances in understanding the genetics and molecular mechanisms determining normal SAN function, and of the pathways controlling remodeling are revealing SAN disease to be heterogeneous. We review the contemporary concepts of SAN function, heart rate adaptation and SAN disease from the molecular level to clinical application.
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