Journal
CIRCULATION JOURNAL
Volume 75, Issue 11, Pages 2513-2521Publisher
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.CJ-11-0967
Keywords
Heart; Mitochondrial dynamics; SUMO; Ubiquitin
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Funding
- National Heart, Lung, and Blood Institute [R01HL104129]
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Mitochondria are dynamic organelles that undergo a constant cycle of division and fusion to maintain their function. The process of mitochondrial fusion has the effect of mixing their content, allowing complementation of protein components, mtDNA repair, and distribution of metabolic intermediates. Fission, on the other hand, enables mitochondria to increase in number and capacity, and to segregate mitochondria for autophagy by the lysosome (mitophagy). Disruption of these protein quality control mechanisms has recently been identified in multiple cardiac diseases, including cardiac hypertrophy, heart failure, dilated cardiomyopathy, and ischemic heart disease, and is intimately tied to mitochondrial control of apoptosis. Proteins that regulate mitochondrial fusion and fission have been discovered, including Mfn1, Mfn2, and Opal (fusion) and Drp1 and Fis1 (fission). In this review, we discuss' how these proteins are regulated by post-translational modification with ubiquitin and SUMO (small ubiquitin-like modifier). We then present what is known about the ubiquitin and SUMO ligases that regulate these post-translational modifications and regulation of mitochondrial fusion and fission, exploring their potential as therapeutic targets of cardiac disease. (Circ J 2011; 75: 2513-2521)
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