Journal
CIRCULATION JOURNAL
Volume 75, Issue 8, Pages 1791-1800Publisher
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.CJ-11-0388
Keywords
NADPH oxidase/Nox; Reactive oxygen species; Vascular diseases
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [21390243]
- Takeda Science Foundation, Japan
- Innovation Center for Medical Redox Navigation, Kyushu University, Japan
- Grants-in-Aid for Scientific Research [21390243] Funding Source: KAKEN
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It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system. (Circ J 2011; 75: 1791-1800)
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