Journal
CIRCULATION JOURNAL
Volume 75, Issue 9, Pages 2151-2159Publisher
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.CJ-10-1072
Keywords
Angiotensin-converting enzyme inhibitor; Curcumin; Heart failure; Hypertrophy
Categories
Funding
- Foundation for Promotion of Research on Adult Vascular Diseases
- Japan Health Sciences Foundation
- Japan Science and Technology Agency
- Japan Research Foundation for Clinical Pharmacology
- Grants-in-Aid for Scientific Research [10J03435, 21590944] Funding Source: KAKEN
Ask authors/readers for more resources
Background: A natural p300-specific histone acetyltransferase (HAT) inhibitor, curcumin, may have therapeutic potential for heart failure. However, it is unclear whether curcumin exhibits beneficial additive or synergistic effects on conventional therapy with angiotensin-converting enzyme inhibitors (ACEIs). Methods and Results: Rats were subjected to a sham operation or left coronary artery ligation. One week later, 34 rats with a moderate sized myocardial infarction (MI) were randomly assigned to 4 groups: solvents as control (n=8), enalapril (an ACEI, 10 mg.kg(-1).day(-1)) alone (n=8), curcumin (50 mg.kg(-1)day(-1)) alone (n=9) and enalapril plus curcumin (n=9). Daily oral treatment was repeated and continued for 6 weeks. Echocardiographic data were similar among the 4 groups before treatment. After treatment, left ventricular (LV) fractional shortening (FS) was significantly higher in the enalapril (29.0 +/- 1.9%) and curcumin (30.8 +/- 1.7%) groups than in the vehicle group (19.7 +/- 1.6%). Notably, LVFS further increased in the enalapril/curcumin combination group (34.4 +/- 1.8%). Histologically, cardiomyocyte diameter in the non-infarct area was smaller in the enalapril/curcumin combination group than in the enalapril group. Perivascular fibrosis was significantly reduced in the enalapril/curcumin group compared with the curcumin group. Conclusions: A natural non-toxic dietary compound, curcumin, combined with an ACEI exerts beneficial effects on post-MI LV systolic function in rats. (Circ J 2011; 75: 2151-2159)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available