Journal
CIRCULATION JOURNAL
Volume 74, Issue 5, Pages 827-835Publisher
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.CJ-10-0153
Keywords
Blood pressure; Brain; Heart rate; Hypertension; Sympathetic nervous system
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Funding
- Japan Society for the Promotion of Science
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Oxidative stress is a key factor in the pathogenesis of hypertension and target organ damage, beginning in the earliest stages. Extensive evidence indicates that the pivotal role of oxidative stress in the pathogenesis of hypertension is due to its effects on the vasculature in relation to the development of atherosclerotic processes. It remains unclear, however, whether oxidative stress in the brain, particularly the autonomic nuclei (including the vasomotor center), has an important role in the occurrence and maintenance of hypertension via activation of the sympathetic nervous system. The aim of the present review is to describe the contribution of oxidative stress in the brain to the neural mechanisms that underlie hypertension, and discuss evidence that brain oxidative stress is a potential therapeutic target. (Circ J 2010; 74: 827-835)
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